X-ray diffraction
2.3Å resolution

Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.


Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Plasminogen activator inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 379 amino acids
Theoretical weight: 42.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 77.438Å b: 67.172Å c: 90.357Å
α: 90° β: 98.5° γ: 90°
R R work R free
0.195 0.193 0.238
Expression system: Escherichia coli BL21(DE3)