X-ray diffraction
2.3Å resolution

Cocaine Esterase, wild-type biologically active dimer


Function and Biology Details

Reaction catalysed:
Cocaine + H(2)O = ecgonine methyl ester + benzoate 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cocaine esterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 587 amino acids
Theoretical weight: 63.71 KDa
Source organism: Rhodococcus sp. MB1 'Bresler 1999'
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9L9D7 (Residues: 1-574; Coverage: 100%)
Gene name: cocE
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 73.345Å b: 105.442Å c: 224.518Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.208 0.249
Expression system: Escherichia coli BL21(DE3)