› 3psl

X-ray diffraction
1.7Å resolution

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic

Released:
DOI: 10.2210/pdb3psl/pdb
PDB entry 3psl coloured by chain, front view.
PDB entry 3psl coloured by chain, side view.
PDB entry 3psl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF
FASEB J 25 960-7 (2011)
PMID: 21135039

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158483 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 318 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 21-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
N-alpha acetylated form of histone H3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 amino acids
Theoretical weight: 631 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P1
Unit cell:
a: 45.947Å b: 48.614Å c: 63.308Å
α: 98.79° β: 90.95° γ: 117.48°
R-values:
R R work R free
0.193 0.155 0.205
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases.
Chopra et al. (2015)
9 other articles

3 mentions without citation

Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins.
Li et al. (2021)
2 more