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Structure of a viral OTU domain protease bound to interferon-stimulated gene 15 (ISG15)

X-ray diffraction
2.3Å resolution
PDB entry 3pse coloured by chain, front view.
PDB entry 3pse coloured by chain, side view.
PDB entry 3pse coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase L and Ubiquitin-like protein ISG15
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Multimeric state: hetero dimer
Accessible surface area: 15035.82 Å2
Buried surface area: 2423.57 Å2
Dissociation area: 1,100.44 Å2
Dissociation energy (ΔGdiss): 1.81 kcal/mol
Dissociation entropy (TΔSdiss): 11.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138567

Macromolecules

RNA-directed RNA polymerase L
Chain: A
Length: 171 amino acids
Theoretical weight: 19.48 KDa
Source organism: Orthonairovirus haemorrhagiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6TQR6 (Residues: 1-169; Coverage: 4%)
Gene name: L
Pfam: OTU-like cysteine protease
InterPro:
CATH: Cathepsin B; Chain A
RNA-directed RNA polymerase L in PDB entry 3pse, assembly 1, front view.
RNA-directed RNA polymerase L in PDB entry 3pse, assembly 1, side view.
RNA-directed RNA polymerase L in PDB entry 3pse, assembly 1, top view.
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Ubiquitin-like protein ISG15
Chain: B
Length: 156 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05161 (Residues: 1-156; Coverage: 95%)
Gene names: G1P2, ISG15, UCRP
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Ubiquitin-like protein ISG15 in PDB entry 3pse, assembly 1, front view.
Ubiquitin-like protein ISG15 in PDB entry 3pse, assembly 1, side view.
Ubiquitin-like protein ISG15 in PDB entry 3pse, assembly 1, top view.
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