3ps5

X-ray diffraction
3.1Å resolution

Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29350 (Residues: 1-595; Coverage: 100%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: R32
Unit cell:
a: 231.919Å b: 231.919Å c: 78.852Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.225 0.276
Expression system: Escherichia coli BL21(DE3)