X-ray diffraction
1.85Å resolution

PDZ domain from Human microtubule-associated serine/threonine-protein kinase 1

Source organism: Homo sapiens
Entry authors: Ugochukwu E, Wang J, Krojer T, Muniz JRC, Sethi R, Pike ACW, Roos A, Salah E, Cocking R, Savitsky P, Doyle DA, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S, Elkins JM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Microtubule-associated serine/threonine-protein kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y2H9 (Residues: 965-1057; Coverage: 6%)
Gene names: KIAA0973, MAST1, SAST
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 62.1Å b: 79.326Å c: 82.856Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.194 0.225
Expression system: Escherichia coli