› 3pp2

X-ray diffraction
1.42Å resolution

Crystal structure of the pleckstrin homology domain of ArhGAP27

Released:
DOI: 10.2210/pdb3pp2/pdb
PDB 3pp2 coloured by chain and viewed from the front.
PDB 3pp2 coloured by chain and viewed from the side.
PDB 3pp2 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Shen L, Tempel W, Tong Y, Nedyalkova L, Li Y, Wernimont AK, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho GTPase-activating protein 27 Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZUM4 (Residues: 491-613; Coverage: 14%)
Gene names: ARHGAP27, CAMGAP1, PP905, SH3D20
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

3 bound ligands:
Ligand CIT 5 x CIT
Ligand UNX 25 x UNX
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 98.243Å b: 98.243Å c: 66.909Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.171 0.192
Expression system: Escherichia coli

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