X-ray diffraction
2.2Å resolution

2.2 Angstrom crystal structure of the complex between Bovine Thrombin and Sucrose Octasulfate

Source organism: Bos taurus
Primary publication:
Interaction of thrombin with sucrose octasulfate.
Biochemistry 50 6973-82 (2011)
PMID: 21736375

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 29 amino acids
Theoretical weight: 3.48 KDa
Source organism: Bos taurus
  • Canonical: P00735 (Residues: 336-364; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
  • Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P43212
Unit cell:
a: 87.562Å b: 87.562Å c: 191.99Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.204 0.245