3pbl

X-ray diffraction
2.89Å resolution

Structure of the human dopamine D3 receptor in complex with eticlopride

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
D(3) dopamine receptor; Endolysin Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 53.65 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
  • Canonical: P35462 (Residues: 2-221, 319-400; Coverage: 76%)
Gene names: DRD3, E
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 88.828Å b: 92.492Å c: 176.116Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.272
Expression system: Spodoptera frugiperda