3pb9

X-ray diffraction
1.12Å resolution

Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole

Released:

Function and Biology Details

Reaction catalysed:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3)
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaminyl-peptide cyclotransferase-like protein Chain: X
Molecule details ›
Chain: X
Length: 330 amino acids
Theoretical weight: 37.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NXS2 (Residues: 53-382; Coverage: 86%)
Gene name: QPCTL
Sequence domains: Peptidase family M28
Structure domains: Zn peptidases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 53.562Å b: 69.202Å c: 77.402Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.151 0.15 0.181
Expression system: Escherichia coli