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Crystal structure of the V130D mutant of OXA-24/40 in complex with doripenem

Source organism: Acinetobacter baumannii
Biochemical function: hydrolase activity
Biological process: cell wall organization
Cellular component: not assigned

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. Penicillin-binding protein transpeptidase domain-containing protein
The deposited structure of PDB entry 3pag contains 2 copies of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in Penicillin-binding protein transpeptidase domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Penicillin-binding protein transpeptidase domain-containing protein
IPR001460
Domain description: Penicillin-binding protein, transpeptidase
Occurring in:
  1. Penicillin-binding protein transpeptidase domain-containing protein

Structure domain

CATH CATH domain
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. Penicillin-binding protein transpeptidase domain-containing protein
The deposited structure of PDB entry 3pag contains 2 copies of CATH domain 3.40.710.10 (Beta-lactamase) in Penicillin-binding protein transpeptidase domain-containing protein. Showing 1 copy in chain A.

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