› 3p72

X-ray diffraction
1.9Å resolution

structure of platelet Glycoprotein 1b alpha with a bound peptide inhibitor

Released:
DOI: 10.2210/pdb3p72/pdb
PDB entry 3p72 coloured by chain, front view.
PDB entry 3p72 coloured by chain, side view.
PDB entry 3p72 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Glycoprotein Ibalpha inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism.
McEwan PA, Andrews RK, Emsley J
Blood 114 4883-5 (2009)
PMID: 19726719

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139562 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycocalicin Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 29.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07359 (Residues: 17-281; Coverage: 42%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor
OS1 peptide Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3121
Unit cell:
a: 58.817Å b: 58.817Å c: 163.027Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.217 0.286
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

Current state and novel approaches of antiplatelet therapy.
Metharom et al. (2015)
1 more

5 mentions without citation

Benchmarking of different molecular docking methods for protein-peptide docking.
Agrawal et al. (2019)
4 more