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Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1997-2016) peptide

X-ray diffraction
2.6Å resolution
PDB entry 3p3p coloured by chain, front view.
PDB entry 3p3p coloured by chain, side view.
PDB entry 3p3p coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxia-inducible factor 1-alpha inhibitor and Notch 1 intracellular domain
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Multimeric state: hetero tetramer
Accessible surface area: 28474.04 Å2
Buried surface area: 10049.31 Å2
Dissociation area: 1,786.63 Å2
Dissociation energy (ΔGdiss): 16.35 kcal/mol
Dissociation entropy (TΔSdiss): 16.29 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-169619

Macromolecules

Hypoxia-inducible factor 1-alpha inhibitor
Chain: A
Length: 349 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWT6 (Residues: 1-349; Coverage: 100%)
Gene names: FIH1, HIF1AN
Pfam: Cupin-like domain
InterPro:
CATH:
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 3p3p, assembly 1, front view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 3p3p, assembly 1, side view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 3p3p, assembly 1, top view.
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Notch 1 intracellular domain
Chain: B
Length: 18 amino acids
Theoretical weight: 1.93 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q01705 (Residues: 1999-2016; Coverage: 1%)
Gene names: Motch, Notch1
Notch 1 intracellular domain in PDB entry 3p3p, assembly 1, front view.
Notch 1 intracellular domain in PDB entry 3p3p, assembly 1, side view.
Notch 1 intracellular domain in PDB entry 3p3p, assembly 1, top view.
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