X-ray diffraction
1.7Å resolution

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

Source organism: Homo sapiens
Entry authors: Chaikuad A, Eswaran J, Fedorov O, Cooper CDO, Kroeler T, Vollmar M, Krojer T, Berridge G, Muniz JRC, Pike ACW, von Delft F, Weigelt J, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q99640 (Residues: 75-362; Coverage: 58%)
Gene names: MYT1, PKMYT1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 45.4Å b: 56.3Å c: 114.66Å
α: 90° β: 90° γ: 90°
R R work R free
0.152 0.15 0.195
Expression system: Escherichia coli