› 3p0l

X-ray diffraction
3.4Å resolution

Human steroidogenic acute regulatory protein

Released:
DOI: 10.2210/pdb3p0l/pdb
PDB entry 3p0l coloured by chain, front view.
PDB entry 3p0l coloured by chain, side view.
PDB entry 3p0l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Comparative structural analysis of lipid binding START domains.
Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schüler H, Lehtiö L
PLoS One 6 e19521 (2011)
PMID: 21738568

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroidogenic acute regulatory protein, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 221 amino acids
Theoretical weight: 24.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49675 (Residues: 66-284; Coverage: 77%)
Gene names: STAR, STARD1
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P63
Unit cell:
a: 144.13Å b: 144.13Å c: 101.03Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.256 0.287
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Early steps in steroidogenesis: intracellular cholesterol trafficking.
Miller et al. (2011)
16 more

8 mentions without citation

STARD3: A Prospective Target for Cancer Therapy.
Asif et al. (2021)
7 more