Structure analysis

Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.

X-ray diffraction
1.75Å resolution
Source organism: HIV-1 M:B_ARV2/SF2
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: homo dimer
Accessible surface area: 9400 Å2
Buried surface area: 5400 Å2
Dissociation area: 2,000 Å2
Dissociation energy (ΔGdiss): 26 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -24 kcal/mol
Symmetry number: 2
Assembly 2 (preferred)
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Multimeric state: homo dimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 99 amino acids
Theoretical weight: 10.83 KDa
Source organism: HIV-1 M:B_ARV2/SF2
Expression system: Escherichia coli
UniProt:
  • Canonical: P03369 (Residues: 491-589; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases

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