› 3ox6

X-ray diffraction
2.4Å resolution

Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)

Released:
DOI: 10.2210/pdb3ox6/pdb
PDB entry 3ox6 coloured by chain, front view.
PDB entry 3ox6 coloured by chain, side view.
PDB entry 3ox6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.
Findeisen F, Minor DL
Structure 18 1617-31 (2010)
PMID: 21134641

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-binding protein 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZU7 (Residues: 219-370; Coverage: 41%)
Gene name: CABP1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 11 x CA
Ligand HEZ 4 x HEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 68.716Å b: 68.716Å c: 344.195Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.252 0.295
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Calmodulin regulation (calmodulation) of voltage-gated calcium channels.
Ben-Johny et al. (2014)
11 more

4 mentions without citation

L-Type Ca2+ Channel Regulation by Calmodulin and CaBP1.
Ames JB. (2021)
3 more