PDBe 3op3

X-ray diffraction
2.63Å resolution

Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens

Released:
Source organism: Homo sapiens
Entry authors: Kim Y, Weger A, Hatzos C, Savitsky P, Johansson C, Ball L, Barr A, Vollmar M, Muniz J, Weigelt J, Arrowsmith CH, Edwards A, Bountra C, Gileadi O, von Delft F, Knapp S, Joachimiak A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
M-phase inducer phosphatase 3 Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 25.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30307 (Residues: 270-462; Coverage: 41%)
Gene name: CDC25C
Sequence domains: Rhodanese-like domain
Structure domains: Rhodanese-like domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 96.187Å b: 96.187Å c: 61.188Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.198 0.218
Expression system: Escherichia coli