3ogi

X-ray diffraction
2.55Å resolution

Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ESAT-6-like protein EsxO Chains: A, C
Molecule details ›
Chains: A, C
Length: 101 amino acids
Theoretical weight: 11.03 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WNI7 (Residues: 1-94; Coverage: 100%)
Gene names: MTCY98.15c, Rv2346c, esxO
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like
ESAT-6-like protein EsxP Chains: B, D
Molecule details ›
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.5 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WNI5 (Residues: 1-98; Coverage: 100%)
Gene names: MTCY98.16c, Rv2347c, esxP
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P3221
Unit cell:
a: 66.383Å b: 66.383Å c: 162.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.26
Expression system: Escherichia coli BL21(DE3)