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Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in I222 spacegroup

Source organisms:
Biochemical function: cytokine binding
Biological process: viral release from host cell by cytolysis
Cellular component: host cell cytoplasm

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EC 3.2.1.17: Lysozyme

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Systematic name:
Peptidoglycan N-acetylmuramoylhydrolase
Alternative Name(s):
  • 1,4-N-acetylmuramidase
  • Globulin G
  • Globulin G1
  • L-7001
  • Lysozyme g
  • Mucopeptide N-acetylmuramoylhydrolase
  • Mucopeptide glucohydrolase
  • Muramidase
  • N,O-diacetylmuramidase
  • PR1-lysozyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00959
Domain description: Phage lysozyme
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
The deposited structure of PDB entry 3oe6 contains 1 copy of Pfam domain PF00959 (Phage lysozyme) in C-X-C chemokine receptor type 4. Showing 1 copy in chain A.

PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
The deposited structure of PDB entry 3oe6 contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in C-X-C chemokine receptor type 4. Showing 1 copy in chain A.

PF12109
Domain description: CXCR4 Chemokine receptor N terminal
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
The deposited structure of PDB entry 3oe6 contains 1 copy of Pfam domain PF12109 (CXCR4 Chemokine receptor N terminal) in C-X-C chemokine receptor type 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001165
Domain description: T4-type lysozyme
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR002196
Domain description: Glycoside hydrolase, family 24
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR023347
Domain description: Lysozyme domain superfamily
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR034690
Domain description: Endolysin T4 type
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
IPR022726
Domain description: CXC chemokine receptor 4 N-terminal domain
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin

Structure domains

CATH CATH domains
1.20.1070.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Rhopdopsin 7-helix transmembrane proteins
Homology: Rhodopsin 7-helix transmembrane proteins
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
The deposited structure of PDB entry 3oe6 contains 1 copy of CATH domain 1.20.1070.10 (Rhopdopsin 7-helix transmembrane proteins) in C-X-C chemokine receptor type 4. Showing 1 copy in chain A.
1.10.530.40
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lysozyme
Homology: Lysozyme
Occurring in:
  1. C-X-C chemokine receptor type 4; Endolysin
The deposited structure of PDB entry 3oe6 contains 1 copy of CATH domain 1.10.530.40 (Lysozyme) in C-X-C chemokine receptor type 4. Showing 1 copy in chain A.

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