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Stable-5-Lipoxygenase

X-ray diffraction
2.389Å resolution
PDB entry 3o8y coloured by chain, front view.
PDB entry 3o8y coloured by chain, side view.
PDB entry 3o8y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Polyunsaturated fatty acid 5-lipoxygenase
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Multimeric state: monomeric
Accessible surface area: 26933.45 Å2
Buried surface area: 137.11 Å2
Dissociation area: 68.55 Å2
Dissociation energy (ΔGdiss): 13.62 kcal/mol
Dissociation entropy (TΔSdiss): 0.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140817
Assembly 2
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Assembly Name: Polyunsaturated fatty acid 5-lipoxygenase
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Multimeric state: monomeric
Accessible surface area: 26521.49 Å2
Buried surface area: 137.08 Å2
Dissociation area: 68.54 Å2
Dissociation energy (ΔGdiss): 13.62 kcal/mol
Dissociation entropy (TΔSdiss): 0.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140817

Macromolecules

Polyunsaturated fatty acid 5-lipoxygenase
Chains: A, B
Length: 691 amino acids
Theoretical weight: 79.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09917 (Residues: 1-674; Coverage: 100%)
Gene names: ALOX5, LOG5
Pfam:
InterPro:
CATH:
Polyunsaturated fatty acid 5-lipoxygenase in PDB entry 3o8y, assembly 1, front view.
Polyunsaturated fatty acid 5-lipoxygenase in PDB entry 3o8y, assembly 1, side view.
Polyunsaturated fatty acid 5-lipoxygenase in PDB entry 3o8y, assembly 1, top view.
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