3o2y

X-ray diffraction
1.7Å resolution

Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid

Released:
Source organism: Homo sapiens
Entry authors: Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu Z-J

Function and Biology Details

Reaction catalysed:
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin-H2 D-isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41222 (Residues: 29-190; Coverage: 96%)
Gene names: PDS, PTGDS
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 90.221Å b: 90.221Å c: 35.635Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.264
Expression system: Escherichia coli