PDBe 3nyj

X-ray diffraction
3.2Å resolution

Crystal Structure Analysis of APP E2 domain

Released:
Source organism: Homo sapiens
Primary publication:
The E2 domains of APP and APLP1 share a conserved mode of dimerization.
Biochemistry 50 5453-64 (2011)
PMID: 21574595

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble APP-beta Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 24.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 365-567; Coverage: 27%)
  • Best match: P05067-7 (Residues: 346-548)
Gene names: A4, AD1, APP
Sequence domains: E2 domain of amyloid precursor protein
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 114.979Å b: 40.149Å c: 58.376Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.306 0.297 0.38
Expression system: Escherichia coli