› 3ntn

X-ray diffraction
2.2Å resolution

Crystal Structure of UspA1 head and neck domain from Moraxella catarrhalis

Released:
DOI: 10.2210/pdb3ntn/pdb
PDB entry 3ntn coloured by chain, front view.
PDB entry 3ntn coloured by chain, side view.
PDB entry 3ntn coloured by chain, top view.
Source organism: Moraxella catarrhalis
Primary publication:
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.
Agnew C, Borodina E, Zaccai NR, Conners R, Burton NM, Vicary JA, Cole DK, Antognozzi M, Virji M, Brady RL
Proc Natl Acad Sci U S A 108 15174-8 (2011)
PMID: 21876142

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UspA1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 220 amino acids
Theoretical weight: 22.2 KDa
Source organism: Moraxella catarrhalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9XD56 (Residues: 153-366; Coverage: 25%)
Gene name: uspA1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand CL 1 x CL
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 50.295Å b: 142.847Å c: 50.268Å
α: 90° β: 119.96° γ: 90°
R-values:
R R work R free
0.185 0.182 0.244
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host.
Singh et al. (2012)
3 more

4 mentions without citation

Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin.
Koiwai et al. (2016)
3 more