Function and Biology Details
Reactions catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thymidylate synthase
- Dihydrofolate reductase domain
- Thymidylate synthase/dCMP hydroxymethylase domain
- Thymidylate synthase/dCMP hydroxymethylase superfamily
- Dihydrofolate reductase-like domain superfamily
- Thymidylate synthase, active site
- Thymidylate synthase/dCMP hydroxymethylase
- Bifunctional dihydrofolate reductase/thymidylate synthase
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108218 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional dihydrofolate reductase-thymidylate synthase
Molecule details ›
Chains: A, B
Length: 515 amino acids
Theoretical weight: 58.58 KDa
Source organism: Babesia bovis
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 515 amino acids
Theoretical weight: 58.58 KDa
Source organism: Babesia bovis
Expression system: Escherichia coli
UniProt:
- Canonical:
A7ASX7 (Residues: 1-511; Coverage: 100%)
Sequence domains:
Structure domains:
