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Plasticity of human CD8αα binding to peptide-HLA-A*2402.

Shi Y, Qi J, Iwamoto A, Gao GF
Mol Immunol 48 2198-202 (2011)
Cited: 21 times
EuropePMC logo PMID: 21645925

Abstract

The human CD8 functions as a co-receptor for specific T cell recognition, and only one complex structure of human CD8αα binding to HLA-A*0201 has been solved, revealing the molecular basis of CD8 interacting with its ligand pHLA. Here, we present the complex structures of human CD8αα bound to HLA-A*2402, which demonstrate two opposite α3 domain CD loop shifts (either pull or push) in the HLA heavy chain upon CD8 engagement. Taking the previously reported mouse CD8-pMHC complex structures into account, from the structural view, all of the data indicate the plasticity of CD8 binding to pMHC/HLA, which facilitates its co-receptor function for T cells. The plasticity of CD8 binding appears not to affect the specificity of TCR recognition, as no peptide conformation change extends to the pMHC interface for TCR contacting.

Reviews citing this publication (4)

  1. The molecular determinants of CD8 co-receptor function. Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK. Immunology 137 139-148 (2012)
  2. Structural and dynamic features of HLA-B27 subtypes. Uchanska-Ziegler B, Ziegler A, Schmieder P. Curr Opin Rheumatol 25 411-418 (2013)
  3. Integrating Experiment and Theory to Understand TCR-pMHC Dynamics. Buckle AM, Borg NA. Front Immunol 9 2898 (2018)
  4. Variations in MHC class I antigen presentation and immunopeptidome selection pathways. Zaitoua AJ, Kaur A, Raghavan M. F1000Res 9 (2020)

Articles citing this publication (17)

  1. Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Wang H, Shi Y, Song J, Qi J, Lu G, Yan J, Gao GF. Cell 164 258-268 (2016)
  2. Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. Yanaka S, Ueno T, Shi Y, Qi J, Gao GF, Tsumoto K, Sugase K. J. Biol. Chem. 289 24680-24690 (2014)
  3. Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules. Hee CS, Beerbaum M, Loll B, Ballaschk M, Schmieder P, Uchanska-Ziegler B, Ziegler A. Immunogenetics 65 157-172 (2013)
  4. NMR spectroscopy reveals unexpected structural variation at the protein-protein interface in MHC class I molecules. Beerbaum M, Ballaschk M, Erdmann N, Schnick C, Diehl A, Uchanska-Ziegler B, Ziegler A, Schmieder P. J. Biomol. NMR 57 167-178 (2013)
  5. Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Li Y, Yin Y, Mariuzza RA. Front Immunol 4 206 (2013)
  6. Superimposed epitopes restricted by the same HLA molecule drive distinct HIV-specific CD8+ T cell repertoires. Sun X, Fujiwara M, Shi Y, Kuse N, Gatanaga H, Appay V, Gao GF, Oka S, Takiguchi M. J Immunol 193 77-84 (2014)
  7. The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM. Immunity 54 132-150.e9 (2021)
  8. Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium. Fan H, Du X, Zhang J, Zheng H, Lu X, Wu Q, Li H, Wang H, Shi Y, Gao G, Zhou Z, Tan DX, Li X. Sci Rep 7 41226 (2017)
  9. High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange. Overall SA, Toor JS, Hao S, Yarmarkovich M, Sara M O'Rourke, Morozov GI, Nguyen S, Japp AS, Gonzalez N, Moschidi D, Betts MR, Maris JM, Smibert P, Sgourakis NG. Nat Commun 11 1909 (2020)
  10. Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the chicken CD8αα-BF2*0401 complex. Liu Y, Chen R, Tariq M, Xia C. Acta Crystallogr F Struct Biol Commun 70 1264-1267 (2014)
  11. Conserved Vδ1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by δ/αβ T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs. Shi Y, Kawana-Tachikawa A, Gao F, Qi J, Liu C, Gao J, Cheng H, Ueno T, Iwamoto A, Gao GF. J. Virol. 91 (2017)
  12. Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation. Sun X, Shi Y, Akahoshi T, Fujiwara M, Gatanaga H, Schönbach C, Kuse N, Appay V, Gao GF, Oka S, Takiguchi M. Cell Rep 15 2279-2291 (2016)
  13. Adding Help to an HLA-A*24:02 Tumor-Reactive γδTCR Increases Tumor Control. Johanna I, Hernández-López P, Heijhuurs S, Scheper W, Bongiovanni L, de Bruin A, Beringer DX, Oostvogels R, Straetemans T, Sebestyen Z, Kuball J. Front Immunol 12 752699 (2021)
  14. The structural basis of chicken, swine and bovine CD8αα dimers provides insight into the co-evolution with MHC I in endotherm species. Liu Y, Li X, Qi J, Zhang N, Xia C. Sci Rep 6 24788 (2016)
  15. CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells. Souter MNT, Awad W, Li S, Pediongco TJ, Meehan BS, Meehan LJ, Tian Z, Zhao Z, Wang H, Nelson A, Le Nours J, Khandokar Y, Praveena T, Wubben J, Lin J, Sullivan LC, Lovrecz GO, Mak JYW, Liu L, Kostenko L, Kedzierska K, Corbett AJ, Fairlie DP, Brooks AG, Gherardin NA, Uldrich AP, Chen Z, Rossjohn J, Godfrey DI, McCluskey J, Pellicci DG, Eckle SBG. J Exp Med 219 e20210828 (2022)
  16. Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles. Serçinoğlu O, Ozbek P. J. Biomol. Struct. Dyn. 36 724-740 (2018)
  17. The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response. Liu Y, Chen R, Liang R, Sun B, Wu Y, Zhang L, Kaufman J, Xia C. Front Immunol 11 605085 (2020)


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