PDBe 3n8m

X-ray diffraction
2Å resolution

Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P62993 (Residues: 53-163)
Gene names: ASH, GRB2
PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 782 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 49.24Å b: 49.24Å c: 86.128Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.224
Expression systems:
  • Escherichia coli
  • Not provided