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Structure of endothelial nitric oxide synthase N368D/V106M double mutant heme domain complexed with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)

X-ray diffraction
2.65Å resolution
PDB entry 3n69 coloured by chain, front view.
PDB entry 3n69 coloured by chain, side view.
PDB entry 3n69 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nitric oxide synthase 1
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Multimeric state: homo dimer
Accessible surface area: 32359.49 Å2
Buried surface area: 10611.54 Å2
Dissociation area: 68.91 Å2
Dissociation energy (ΔGdiss): 40.76 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151520

Macromolecules

Nitric oxide synthase 1
Chains: A, B
Length: 444 amino acids
Theoretical weight: 49.74 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P29476 (Residues: 280-293, 294-340, 341-711; Coverage: 30%)
Gene names: Bnos, Nos1
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
CATH:
Nitric oxide synthase 1 in PDB entry 3n69, assembly 1, front view.
Nitric oxide synthase 1 in PDB entry 3n69, assembly 1, side view.
Nitric oxide synthase 1 in PDB entry 3n69, assembly 1, top view.
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