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Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)

X-ray diffraction
3.03Å resolution
PDB entry 3n57 coloured by chain, front view.
PDB entry 3n57 coloured by chain, side view.
PDB entry 3n57 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin-degrading enzyme and Atrial natriuretic peptide
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Multimeric state: hetero tetramer
Accessible surface area: 76169.19 Å2
Buried surface area: 2978.69 Å2
Dissociation area: 1,387.65 Å2
Dissociation energy (ΔGdiss): -10.29 kcal/mol
Dissociation entropy (TΔSdiss): 24.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134082

Macromolecules

Insulin-degrading enzyme
Chains: A, B
Length: 990 amino acids
Theoretical weight: 114.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14735 (Residues: 42-1019; Coverage: 96%)
Gene name: IDE
Pfam:
InterPro:
CATH: Metalloenzyme, LuxS/M16 peptidase-like
Insulin-degrading enzyme in PDB entry 3n57, assembly 1, front view.
Insulin-degrading enzyme in PDB entry 3n57, assembly 1, side view.
Insulin-degrading enzyme in PDB entry 3n57, assembly 1, top view.
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Atrial natriuretic peptide
Chains: C, D
Length: 28 amino acids
Theoretical weight: 3.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01160 (Residues: 124-151; Coverage: 22%)
Gene names: ANP, NPPA, PND
Pfam: Atrial natriuretic peptide
InterPro:
Atrial natriuretic peptide in PDB entry 3n57, assembly 1, front view.
Atrial natriuretic peptide in PDB entry 3n57, assembly 1, side view.
Atrial natriuretic peptide in PDB entry 3n57, assembly 1, top view.
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