› 3n2m

X-ray diffraction
1.8Å resolution

Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP

Released:
DOI: 10.2210/pdb3n2m/pdb
PDB entry 3n2m coloured by chain, front view.
PDB entry 3n2m coloured by chain, side view.
PDB entry 3n2m coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Liu Y, Kotra LP, Pai EF

Function and Biology Details

Reaction catalysed: 
Orotidine 5'-phosphate = UMP + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
orotidine-5'-phosphate decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 342 amino acids
Theoretical weight: 39.9 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IJH3 (Residues: 1-323; Coverage: 100%)
Gene name: PF3D7_1023200
Sequence domains: Orotidine 5'-phosphate decarboxylase / HUMPS family
Structure domains: Aldolase class I

Ligands and Environments

5 bound ligands:
Ligand FNU 2 x FNU
Ligand TRS 1 x TRS
Ligand PEG 1 x PEG
Ligand SO4 1 x SO4
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21212
Unit cell:
a: 80.64Å b: 83.35Å c: 89.843Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.189
Expression system: Escherichia coli BL21(DE3)

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