› 3myg

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14965 (Residues: 125-391; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PG4 1 x PG4
Ligand EML 1 x EML
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6122
Unit cell:
a: 80.88Å b: 80.88Å c: 171.282Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.221 0.245
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy.
Du et al. (2021)
1 more

5 mentions without citation

Protein-Ligand Scoring with Convolutional Neural Networks.
Ragoza et al. (2017)
4 more