› 3mxi

X-ray diffraction
2.55Å resolution

TREX1 3' Exonuclease D18N Familial Chilblain Lupus Mutant

Released:
DOI: 10.2210/pdb3mxi/pdb
PDB entry 3mxi coloured by chain, front view.
PDB entry 3mxi coloured by chain, side view.
PDB entry 3mxi coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Bailey SL, Hollis T

Function and Biology Details

Reaction catalysed: 
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116596 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Three-prime repair exonuclease 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.32 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91XB0 (Residues: 1-242; Coverage: 77%)
Gene name: Trex1
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
DNA (5'-D(*GP*AP*CP*G)-3') Chains: C, D
Molecule details ›
Chains: C, D
Length: 4 nucleotides
Theoretical weight: 1.22 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 64.028Å b: 58.776Å c: 66.523Å
α: 90° β: 110.33° γ: 90°
R-values:
R R work R free
0.212 0.209 0.262
Expression systems:
  • Escherichia coli
  • Not provided

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