› 3mwp

X-ray diffraction
1.8Å resolution

Nucleoprotein structure of lassa fever virus

Released:
DOI: 10.2210/pdb3mwp/pdb
PDB entry 3mwp coloured by chain, front view.
PDB entry 3mwp coloured by chain, side view.
PDB entry 3mwp coloured by chain, top view.
Source organism: Lassa virus Josiah
Primary publication:
Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang Y, Dong C
Nature 468 779-83 (2010)
PMID: 21085117

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146710 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 577 amino acids
Theoretical weight: 63.97 KDa
Source organism: Lassa virus Josiah
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13699 (Residues: 1-569; Coverage: 100%)
Gene name: N
Sequence domains:
Structure domains: Arenaviral nucleoprotein, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P3
Unit cell:
a: 176.82Å b: 176.82Å c: 56.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.178 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

53 review citations

Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis.
Liu et al. (2014)
52 more

14 mentions without citation

Inhibition of Innate Immune Responses Is Key to Pathogenesis by Arenaviruses.
Meyer et al. (2016)
13 more