PDBe 3mu6

X-ray diffraction
2.43Å resolution

Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Myocyte-specific enhancer factor 2A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 71 amino acids
Theoretical weight: 8.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02078 (Residues: 2-72; Coverage: 14%)
Gene names: MEF2, MEF2A
Sequence domains: SRF-type transcription factor (DNA-binding and dimerisation domain)
Structure domains: Transcription factor, MADS-box
DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3') Chains: E, G
Molecule details ›
Chains: E, G
Length: 17 nucleotides
Theoretical weight: 5.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3') Chains: F, H
Molecule details ›
Chains: F, H
Length: 17 nucleotides
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P1
Unit cell:
a: 41.567Å b: 61.622Å c: 61.478Å
α: 114.12° β: 89.99° γ: 89.95°
R-values:
R R work R free
0.231 0.23 0.251
Expression systems:
  • Escherichia coli
  • Not provided