X-ray diffraction
3.3Å resolution

Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol 3-kinase regulatory subunit beta Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 22.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: O00459 (Residues: 433-610; Coverage: 25%)
Gene name: PIK3R2
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: R32
Unit cell:
a: 174.588Å b: 174.588Å c: 102.699Å
α: 90° β: 90° γ: 120°
R R work R free
0.25 0.249 0.277
Expression system: Escherichia coli BL21