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Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate

Source organism: Homo sapiens
Biochemical function: inositol phosphate phosphatase activity
Biological process: phosphatidylinositol dephosphorylation
Cellular component: not assigned

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EC 3.1.3.36: Phosphoinositide 5-phosphatase

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Systematic name:
Phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Alternative Name(s):
  • Diphosphoinositide phosphatase
  • IP(3) phosphatase
  • Inositol 1,4,5-triphosphate 5-phosphomonoesterase
  • Inositol triphosphate 5-phosphomonoesterase
  • Phosphatidyl-inositol-bisphosphate phosphatase
  • Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase
  • Phosphatidylinositol 4,5-bisphosphate phosphatase
  • Phosphatidylinositol-bisphosphatase
  • Polyphosphoinositol lipid 5-phosphatase
  • PtdIns(4,5)P(2) phosphatase
  • Triphosphoinositide phosphatase
  • Triphosphoinositide phosphomonoesterase
  • Type II inositol polyphosphate 5-phosphatase
  • Type II inositol-1,4,5-trisphosphate 5-phosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase
IPR037793
Domain description: OCRL1/INPP5B, INPP5c domain
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase
IPR000300
Domain description: Inositol polyphosphate-related phosphatase
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase
IPR046985
Domain description: Inositol 5-phosphatase
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase

Structure domain

CATH CATH domain
3.60.10.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Deoxyribonuclease I; Chain A
Homology: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Type II inositol 1,4,5-trisphosphate 5-phosphatase
The deposited structure of PDB entry 3mtc contains 1 copy of CATH domain 3.60.10.10 (Deoxyribonuclease I; Chain A) in Type II inositol 1,4,5-trisphosphate 5-phosphatase. Showing 1 copy in chain A.

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