› 3msh

X-ray diffraction
1.51Å resolution

Crystal structure of Hepatitis B X-Interacting Protein at high resolution

Released:
DOI: 10.2210/pdb3msh/pdb
PDB entry 3msh coloured by chain, front view.
PDB entry 3msh coloured by chain, side view.
PDB entry 3msh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.
Garcia-Saez I, Lacroix FB, Blot D, Gabel F, Skoufias DA
J Mol Biol 405 331-40 (2011)
PMID: 21059355

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ragulator complex protein LAMTOR5 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43504 (Residues: 1-91; Coverage: 100%)
Gene names: HBXIP, LAMTOR5, XIP
Sequence domains: Ragulator complex protein LAMTOR5
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

4 bound ligands:
Ligand GOL 1 x GOL
Ligand IPA 3 x IPA
Ligand PO4 1 x PO4
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 49.161Å b: 49.161Å c: 72.195Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.212
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Amino acid signalling upstream of mTOR.
Jewell et al. (2013)
2 more

8 mentions without citation

Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II.
Levine et al. (2013)
7 more