› 3moa

X-ray diffraction
2.3Å resolution

Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced Fab) with 17 aa gp41 MPER-derived peptide

Released:
DOI: 10.2210/pdb3moa/pdb
PDB entry 3moa coloured by chain, front view.
PDB entry 3moa coloured by chain, side view.
PDB entry 3moa coloured by chain, top view.
Source organisms:
Entry authors: Nicely NI, Dennison SM, Kelsoe G, Liao H-X, Alam SM, Haynes BF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209100 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transmembrane protein gp41 Chain: P
Molecule details ›
Chain: P
Length: 18 amino acids
Theoretical weight: 2.13 KDa
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P04580 (Residues: 653-669; Coverage: 2%)
Gene name: env
ANTI-HIV-1 ANTIBODY 2F5 LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
ANTI-HIV-1 ANTIBODY 2F5 HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 237 amino acids
Theoretical weight: 25.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 58.82Å b: 65.229Å c: 174.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.219
Expression systems:
  • Not provided
  • Homo sapiens

Quick links