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Crystal structure of the E. coli pyrimidine nucleoside hydrolase YeiK (Apo-form)

Source organism: Escherichia coli K-12
Biochemical function: ribosylpyrimidine nucleosidase activity
Biological process: pyrimidine ribonucleoside catabolic process
Cellular component: cytosol

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EC 3.2.2.8: Ribosylpyrimidine nucleosidase

Reaction catalysed:
A pyrimidine nucleoside + H(2)O = D-ribose + a pyrimidine base
Systematic name:
Pyrimidine-nucleoside ribohydrolase
Alternative Name(s):
  • N-ribosylpyrimidine nucleosidase
  • N-ribosylpyrimidine ribohydrolase
  • Nucleoside ribohydrolase
  • Pyrimidine nucleosidase
  • RihB
  • YeiK

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01156
Domain description: Inosine-uridine preferring nucleoside hydrolase
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
The deposited structure of PDB entry 3mkm contains 4 copies of Pfam domain PF01156 (Inosine-uridine preferring nucleoside hydrolase) in Pyrimidine-specific ribonucleoside hydrolase RihB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036452
Domain description: Ribonucleoside hydrolase-like
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
IPR015910
Domain description: Inosine/uridine-preferring nucleoside hydrolase, conserved site
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
IPR001910
Domain description: Inosine/uridine-preferring nucleoside hydrolase domain
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
IPR023186
Domain description: Inosine/uridine-preferring nucleoside hydrolase
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
IPR022977
Domain description: Pyrimidine-specific ribonucleoside hydrolase RihB
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB

Structure domain

CATH CATH domain
3.90.245.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Inosine-uridine Nucleoside N-ribohydrolase; Chain A
Homology: Ribonucleoside hydrolase-like
Occurring in:
  1. Pyrimidine-specific ribonucleoside hydrolase RihB
The deposited structure of PDB entry 3mkm contains 4 copies of CATH domain 3.90.245.10 (Inosine-uridine Nucleoside N-ribohydrolase; Chain A) in Pyrimidine-specific ribonucleoside hydrolase RihB. Showing 1 copy in chain A.

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