3mjr

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reactions catalysed:
ATP + deoxyadenosine = ADP + dAMP
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidine kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 279 amino acids
Theoretical weight: 32.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41
Unit cell:
a: 97.31Å b: 97.31Å c: 121.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.258 0.312
Expression system: Escherichia coli