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Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb

X-ray diffraction
3Å resolution
PDB entry 3mia coloured by chain, front view.
PDB entry 3mia coloured by chain, side view.
PDB entry 3mia coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Positive transcription elongation factor B, CDK9-cyclinT1 complex and Protein Tat
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Multimeric state: hetero trimer
Accessible surface area: 29495.96 Å2
Buried surface area: 6180.04 Å2
Dissociation area: 1,165.96 Å2
Dissociation energy (ΔGdiss): 2.96 kcal/mol
Dissociation entropy (TΔSdiss): 13.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130018

Macromolecules

Cyclin-dependent kinase 9
Chain: A
Length: 351 amino acids
Theoretical weight: 40.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50750 (Residues: 1-345; Coverage: 93%)
Gene names: CDC2L4, CDK9, TAK
Pfam: Protein kinase domain
InterPro:
CATH:
Cyclin-dependent kinase 9 in PDB entry 3mia, assembly 1, front view.
Cyclin-dependent kinase 9 in PDB entry 3mia, assembly 1, side view.
Cyclin-dependent kinase 9 in PDB entry 3mia, assembly 1, top view.
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Cyclin-T1
Chain: B
Length: 266 amino acids
Theoretical weight: 30.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60563 (Residues: 1-266; Coverage: 37%)
Gene name: CCNT1
Pfam:
InterPro:
CATH: Cyclin-like
Cyclin-T1 in PDB entry 3mia, assembly 1, front view.
Cyclin-T1 in PDB entry 3mia, assembly 1, side view.
Cyclin-T1 in PDB entry 3mia, assembly 1, top view.
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Protein Tat
Chain: C
Length: 86 amino acids
Theoretical weight: 9.85 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04608 (Residues: 1-86; Coverage: 100%)
Gene name: tat
Pfam: Transactivating regulatory protein (Tat)
InterPro:
Protein Tat in PDB entry 3mia, assembly 1, front view.
Protein Tat in PDB entry 3mia, assembly 1, side view.
Protein Tat in PDB entry 3mia, assembly 1, top view.
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