3mdb

X-ray diffraction
2.95Å resolution

Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4

Released:
Source organism: Homo sapiens
Entry authors: Shen L, Tong Y, Tempel W, MacKenzie F, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kinesin-like protein KIF13B Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQT8 (Residues: 440-545; Coverage: 6%)
Gene names: GAKIN, KIAA0639, KIF13B
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
Arf-GAP with dual PH domain-containing protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 392 amino acids
Theoretical weight: 45.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75689 (Residues: 1-374; Coverage: 100%)
Gene names: ADAP1, CENTA1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P41212
Unit cell:
a: 115.797Å b: 115.797Å c: 189.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.277
Expression system: Escherichia coli