X-ray diffraction
1.85Å resolution

Crystal Structure of Human Augmenter of Liver Regeneration (ALR)


Function and Biology Details

Reaction catalysed:
2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
FAD-linked sulfhydryl oxidase ALR Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 139 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P55789 (Residues: 81-205; Coverage: 61%)
Gene names: ALR, GFER, HERV1, HPO
Sequence domains: Erv1 / Alr family
Structure domains: ERV/ALR sulfhydryl oxidase domain

Ligands and Environments

Cofactor: Ligand FAD 3 x FAD
3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 112.719Å b: 65.145Å c: 63.767Å
α: 90° β: 89.97° γ: 90°
R R work R free
0.191 0.189 0.231
Expression system: Escherichia coli BL21(DE3)