Assemblies
Assembly Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Multimeric state:
homo dimer
Accessible surface area:
36890.02 Å2
Buried surface area:
6347.13 Å2
Dissociation area:
2,157.58
Å2
Dissociation energy (ΔGdiss):
30.07
kcal/mol
Dissociation entropy (TΔSdiss):
14.7
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-131150
Macromolecules
Chains: A, B
Length: 422 amino acids
Theoretical weight: 47.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
Length: 422 amino acids
Theoretical weight: 47.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O75874 (Residues: 1-414; Coverage: 100%)
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
- Isocitrate dehydrogenase NADP-dependent
- Isopropylmalate dehydrogenase-like domain
- Isocitrate/isopropylmalate dehydrogenase, conserved site
![Isocitrate dehydrogenase [NADP] cytoplasmic in PDB entry 3mar, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/3mar_entity_1_front_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>3mar</span> contains 2 copies of <span class='highlight'>Isocitrate dehydrogenase [NADP] cytoplasmic</span>. Front view.")
![Isocitrate dehydrogenase [NADP] cytoplasmic in PDB entry 3mar, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/3mar_entity_1_side_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>3mar</span> contains 2 copies of <span class='highlight'>Isocitrate dehydrogenase [NADP] cytoplasmic</span>. Side view.")
![Isocitrate dehydrogenase [NADP] cytoplasmic in PDB entry 3mar, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/3mar_entity_1_top_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>3mar</span> contains 2 copies of <span class='highlight'>Isocitrate dehydrogenase [NADP] cytoplasmic</span>. Top view.")