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Crystal Structure of Human Methionine-R-Sulfoxide Reductase B1 (MsrB1)

Source organism: Homo sapiens
Biochemical function: peptide-methionine (R)-S-oxide reductase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.8.4.14: L-methionine (R)-S-oxide reductase

Reaction catalysed:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin
Systematic name:
L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (R)-S-oxide-forming)
Alternative Name(s):
  • FRMsr
  • FRMsr
  • Free met-R-(o) reductase
  • Free-methionine (R)-S-oxide reductase

EC 1.8.4.12: Peptide-methionine (R)-S-oxide reductase

Reaction catalysed:
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin
Systematic name:
Peptide-methionine:thioredoxin-disulfide S-oxidoreductase (methionine (R)-S-oxide-forming)
Alternative Name(s):
  • Methionine S-oxide reductase
  • Methionine S-oxide reductase (R-form oxidizing)
  • Methionine sulfoxide reductase
  • Methionine sulfoxide reductase B
  • MsrB
  • PMRsr
  • PMSR
  • PilB
  • SelR
  • SelX
  • Selenoprotein R

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01641
Domain description: SelR domain
Occurring in:
  1. Methionine-R-sulfoxide reductase B1
The deposited structure of PDB entry 3mao contains 1 copy of Pfam domain PF01641 (SelR domain) in Methionine-R-sulfoxide reductase B1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002579
Domain description: Peptide methionine sulphoxide reductase MrsB domain
Occurring in:
  1. Methionine-R-sulfoxide reductase B1
IPR011057
Domain description: Mss4-like superfamily
Occurring in:
  1. Methionine-R-sulfoxide reductase B1

Structure domain

CATH CATH domain
2.170.150.20
Class: Mainly Beta
Architecture: Beta Complex
Topology: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
Homology: Peptide methionine sulfoxide reductase.
Occurring in:
  1. Methionine-R-sulfoxide reductase B1
The deposited structure of PDB entry 3mao contains 1 copy of CATH domain 2.170.150.20 (Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A) in Methionine-R-sulfoxide reductase B1. Showing 1 copy in chain A.

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