PDBe 3mao

X-ray diffraction
1.42Å resolution

Crystal Structure of Human Methionine-R-Sulfoxide Reductase B1 (MsrB1)

Released:
Source organism: Homo sapiens
Entry authors: Chaikuad A, Shafqat N, Yue WW, Savitsky P, Krojer T, Ugochukwu E, Muniz JRC, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine-R-sulfoxide reductase B1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZV6 (Residues: 10-112; Coverage: 89%)
Gene names: HSPC270, MSRB1, SEPX1
Structure domains: Peptide methionine sulfoxide reductase.

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 34.054Å b: 47.473Å c: 57.809Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.14 0.17
Expression system: Escherichia coli