Assemblies
Assembly Name:
LDLR-PCSK9 complex
Multimeric state:
hetero trimer
Accessible surface area:
45425.62 Å2
Buried surface area:
3811.41 Å2
Dissociation area:
524.21
Å2
Dissociation energy (ΔGdiss):
-4.9
kcal/mol
Dissociation entropy (TΔSdiss):
14.36
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-134047
Macromolecules
Chain: A
Length: 124 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Peptidase inhibitor I9
InterPro:
Length: 124 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8NBP7 (Residues: 29-152; Coverage: 18%)
Pfam: Peptidase inhibitor I9
InterPro:
Chain: B
Length: 546 amino acids
Theoretical weight: 58.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
Length: 546 amino acids
Theoretical weight: 58.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Pfam:
- Subtilase family
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Peptidase S8/S53 domain superfamily
- Proteinase K-like catalytic domain
- Peptidase S8, subtilisin-related
- Peptidase S8/S53 domain
- Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1
- Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2
- Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3
Chain: C
Length: 791 amino acids
Theoretical weight: 87.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
Length: 791 amino acids
Theoretical weight: 87.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P01130 (Residues: 4-788; Coverage: 91%)
Pfam:
- Low-density lipoprotein receptor domain class A
- Low-density lipoprotein receptor repeat class B
- Coagulation Factor Xa inhibitory site
- LDL receptor-like superfamily
- Low-density lipoprotein (LDL) receptor class A repeat
- Low-density lipoprotein (LDL) receptor class A, conserved site
- Growth factor receptor cysteine-rich domain superfamily
- EGF-like domain
- EGF-like calcium-binding domain
- EGF-type aspartate/asparagine hydroxylation site
- EGF-like calcium-binding, conserved site
- Six-bladed beta-propeller, TolB-like
- LDLR class B repeat