3m0c

X-ray diffraction
7.01Å resolution

The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor

Released:
Source organism: Homo sapiens
Entry authors: Spraggon G, Hampton EN

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 29-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 546 amino acids
Theoretical weight: 58.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Low-density lipoprotein receptor Chain: C
Molecule details ›
Chain: C
Length: 791 amino acids
Theoretical weight: 87.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01130 (Residues: 4-788; Coverage: 91%)
Gene name: LDLR
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P65
Unit cell:
a: 322.906Å b: 322.906Å c: 76.733Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.342 0.341 0.362
Expression system: Homo sapiens