PDBe 3lmk

X-ray diffraction
2.44Å resolution

Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate

Released:
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, Cossar D, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 55.44 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P41594 (Residues: 18-505; Coverage: 41%)
Gene names: GPRC1E, GRM5, MGLUR5
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 71.875Å b: 98.346Å c: 155.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.281
Expression system: unidentified baculovirus