› 3lee

X-ray diffraction
3.2Å resolution

Crystal structure of the human squalene synthase complexed with BPH-652

Released:
DOI: 10.2210/pdb3lee/pdb
PDB entry 3lee coloured by chain, front view.
PDB entry 3lee coloured by chain, side view.
PDB entry 3lee coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu Y-L, Lin F-Y, Oldfield E

Function and Biology Details

Reaction catalysed: 
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153385 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene synthase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 340 amino acids
Theoretical weight: 39.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37268 (Residues: 31-370; Coverage: 82%)
Gene name: FDFT1
Sequence domains: Squalene/phytoene synthase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
Ligand B65 6 x B65
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 85.662Å b: 153.422Å c: 92.904Å
α: 90° β: 90.5° γ: 90°
R-values:
R R work R free
0.196 0.191 0.276
Expression system: Escherichia coli

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